Global analysis of lysine ubiquitination by ubiquitin remnant immunoaffinity profiling
نویسندگان
چکیده
منابع مشابه
Global Analysis of Ubiquitination
The covalent attachment of the small protein ubiquitin to other proteins is known to control a host of biological pathways and is emerging as an important regulatory factor in various processes specific to the nervous system. Ubiquitination is also tightly linked to most neurodegenerative disorders. A quantitative, proteome-wide view of the dynamic changes in ubiquitin modification associated w...
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Ubiquitination controls a broad range of cellular functions. The last step of the ubiquitination pathway is regulated by enzyme type 3 (E3) ubiquitin ligases. E3 enzymes are responsible for substrate specificity and catalyze the formation of an isopeptide bond between a lysine residue of the substrate (or the N terminus of the substrate) and ubiquitin. MIR1 and MIR2 are two E3 ubiquitin ligases...
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ژورنال
عنوان ژورنال: Nature Biotechnology
سال: 2010
ISSN: 1087-0156,1546-1696
DOI: 10.1038/nbt.1654